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effects globalization linguistic assignment writer top thesis proposal editing services beauty black book report custom analysis essay editing for hire us biology coursework trypsin business plan pro 1 tips for writing a literary research paper cheap critical essay writers websites for university writing and designing resume cover letter examples academics Descubrimiento puede acercar a los científicos a desarrollar tratamientos para la pérdida auditiva- Audifono.net

Descubrimiento puede acercar a los científicos a desarrollar tratamientos para la pérdida auditiva

Un nuevo descubrimiento de un equipo dirigido por investigadores de Massachusetts Eye and Ear puede acercar a los científicos al desarrollo de tratamientos que vuelvan a crecer las células perdidas que causan la pérdida auditiva.

En un nuevo estudio, publicado en línea el 4 de diciembre de 2019, en Nature Communications , los científicos informan la identificación de una nueva vía vinculada a la división celular en el oído.

Con esta vía, pudieron reprogramar las células del oído interno para proliferar y regenerar células similares a las células ciliadas en modelos de ratones adultos.

Este estudio de prueba de concepto, el primero de su tipo, puede proporcionar a los científicos un camino hacia la regeneración de las células ciliadas sensoriales y otros tipos importantes de células del oído interno en personas con pérdida auditiva.

“Este artículo es el primero en mostrar que mediante la reprogramación, se puede inducir a las células maduras del oído interno de mamíferos a dividirse y convertirse en células ciliadas, que son necesarias para la audición. Estos hallazgos de una proliferación renovada y una generación eficiente de células ciliadas en un oído interno completamente maduro sientan las bases para la aplicación de la reprogramación y la regeneración de las células ciliadas “. – Zheng-Yi Chen, DPhil, autor principal del estudio, científico asociado de los laboratorios Eaton-Peabody en Mass. Eye and Ear, y profesor asociado de otorrinolaringología: cirugía de cabeza y cuello en la Facultad de Medicina de Harvard

Según las estadísticas federales, la pérdida auditiva es una de las formas más comunes de déficit sensorial en las personas y afecta a unos 37 millones de estadounidenses.

Las células del oído interno de humanos y otros mamíferos carecen de la capacidad de dividirse o regenerarse; por lo tanto, el daño al oído interno, en particular a las células ciliadas, conduce a la muerte celular irreversible y eventual pérdida permanente de la audición.

Las células ciliadas son las células especializadas del oído interno que convierten las vibraciones mecánicas de las ondas sonoras en señales eléctricas que el cerebro puede interpretar, y las personas con formas genéticas de pérdida auditiva pueden sufrir una mutación que destruye estas células.

Actualmente no hay tratamientos farmacéuticos disponibles para la pérdida auditiva.

Reprogramación de las células del oído interno para dividirse utilizando factores de transcripción

Investigaciones previas durante varias décadas han demostrado que en el oído interno del ratón recién nacido, se puede inducir a las células a dividir y regenerar las células ciliadas. Sin embargo, en los oídos internos de ratones completamente maduros, esta capacidad de división celular se pierde y la regeneración de las células ciliadas se ve afectada. En los humanos, sin embargo, incluso un oído interno recién nacido está completamente maduro.

Por lo tanto, el Dr. Chen y sus colegas dijeron que para desarrollar un nuevo tratamiento para la pérdida auditiva humana, “es esencial demostrar que la división celular y la regeneración de las células ciliadas se pueden lograr en el oído interno de los mamíferos maduros”.

En el nuevo estudio, el laboratorio del Dr. Chen utilizó un enfoque de reprogramación mediante la activación de dos factores de transcripción, Myc y Notch, en el oído interno del ratón adulto.

Descubrieron que las células del oído interno completamente maduras pueden ser inducidas a dividirse y más, que muchas células reprogramadas del oído interno pueden ser inducidas para regenerar las células ciliadas de manera eficiente in vivo o en un organismo vivo.

Es importante destacar que las nuevas células ciliadas tenían características de células ciliadas auditivas especializadas, con la presencia de canales de transducción y podían formar conexiones con las neuronas auditivas.

La pérdida de audición puede ser causada por la pérdida de muchos tipos de células del oído interno. La capacidad de las células restantes para dividirse y repoblarse es una forma de lograr la regeneración, lo que podría conducir a la recuperación auditiva.

“Nuestro trabajo reveló que la reprogramación se logra mediante la reactivación de genes de desarrollo tempranos del oído interno para que el oído interno maduro recupere las propiedades del oído interno joven, lo que les permite volver a dividirse y regenerarse”, explicó el Dr. Chen.

La investigación futura mira hacia objetivos para tratamientos farmacéuticos

Este trabajo se basa en un estudio de 2014 de este equipo de investigación que identifica el papel de Notch en la proliferación de células ciliadas. En ese estudio, el equipo del Dr. Chen demostró que Notch está involucrado en la proliferación y regeneración de las células ciliadas en el oído interno del ratón neonatal.

“El aspecto más significativo del estudio actual es el hecho de que el oído interno de los mamíferos completamente maduros aún conserva la capacidad de dividirse y regenerarse si se reprograma lo suficiente, lo que elimina una barrera fundamental que ha impedido que se desarrolle la regeneración del oído interno necesaria para restaurar escuchando “, el Dr. Chen dio más detalles.

El laboratorio del Dr. Chen está trabajando en el descubrimiento de moléculas similares a las drogas para lograr la división celular y la regeneración de las células ciliadas en el oído interno maduro y en modelos animales grandes, incluidos los cerdos.

“Esperamos que nuestra investigación pueda servir como modelo para la regeneración de otros tejidos con propiedades similares que no pueden regenerar las células, como en la retina y el sistema nervioso central”, agregó.

Fuente: Infoacufenos.com


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