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Avance del tinnitus: primer tratamiento eficaz y viable para el zumbido en los oídos

Los científicos han reconectado con éxito, y de forma no invasiva, el cerebro de 326 personas que sufrían de tinnitus, el irritante y, a veces, debilitante zumbido fantasma en los oídos. Los científicos han reconfigurado el cerebro para suprimir el tinnitus mediante una combinación de sonidos y descargas en la lengua, según refiere un artículo escrito por John Elder.

El tinnitus afecta hasta al 15 por ciento de la población y no existen dispositivos médicos ni tratamientos farmacológicos aprobados. Millones de personas en todo el mundo lo han soportado durante años. Y algunos de ellos sufren un efecto significativo en su calidad de vida.

Eso puede estar a punto de cambiar.

El ensayo clínico más largo y más grande de este tipo ha finalizado con la ciencia que muestra cómo podría ser un tratamiento exitoso.

El equipo multinacional de investigadores informa que el 86 por ciento de los participantes del ensayo, de los que siguieron el tratamiento durante 12 semanas, experimentaron una reducción sustancial en la gravedad de sus síntomas.

Muchos experimentaron un beneficio sostenido durante un año después del tratamiento.

¿Cómo se logró esto?

El tratamiento utiliza una técnica llamada “neuromodulación bimodal”, en la que el cerebro cambia o se modifica mediante dos tipos diferentes de estimulación. En el experimento de tinnitus, los investigadores desarrollaron un dispositivo que combina “sonidos con zaps en la lengua”.

Los participantes del ensayo usaron el dispositivo durante una hora al día durante 12 semanas. Imagen: B. Conlon et al.
Según el coautor del estudio, Hubert Lim, profesor asociado de ingeniería biomédica y otorrinolaringología en la Universidad de Minnesota, este tratamiento “se dirige a un subconjunto de células cerebrales que se activan de forma anormal”.

A través de estudios tanto en humanos como en animales, el equipo del Dr. Lim y otros informaron anteriormente que “las neuronas sensibles al tacto estimulantes eléctricamente en la lengua o la cara pueden activar neuronas en el sistema auditivo”. Emparejar estos zaps con sonidos “parece reconfigurar los circuitos cerebrales asociados con el tinnitus”.

La prueba

El ensayo clínico aleatorizado se realizó con pacientes en hospitales de Irlanda y Alemania. Los participantes padecían diferentes tipos de acúfenos. ( Hay cuatro tipos ). Hubo resultados terapéuticos consistentes en ambos sitios clínicos, sin eventos adversos graves. A los 326 participantes se les indicó que usaran el dispositivo durante 60 minutos todos los días durante 12 semanas.

El dispositivo ahora tiene la marca para el mercado como Lenire®, desarrollado por la compañía irlandesa Neuromod Devices.

Consiste en auriculares inalámbricos que entregan secuencias de tonos de audio con capas de ruido de banda ancha a ambos oídos, combinados con pulsos de estimulación eléctrica entregados a 32 electrodos en la punta de la lengua por un dispositivo patentado registrado como Tonguetip.

Antes de utilizar el tratamiento por primera vez, el dispositivo se “configuró para el perfil auditivo del paciente y se optimizó al nivel de sensibilidad del paciente para la estimulación de la lengua”.

El dispositivo redujo los síntomas del tinnitus y estas mejoras persistieron durante un período de seguimiento de 12 meses. Los investigadores señalan que actualmente están llevando a cabo otro gran ensayo clínico para estudiar los efectos de cambiar el protocolo de estimulación a lo largo del tiempo.

De los 326 participantes inscritos, el 83,7 por ciento usó el dispositivo en o por encima del nivel mínimo de cumplimiento de 36 horas durante el período de tratamiento de 12 semanas.

Los participantes lograron “una reducción estadística y clínicamente significativa en la gravedad de los síntomas del tinnitus”. Los investigadores concluyeron que sus resultados “respaldan la seguridad y la utilidad potencial de la neuromodulación bimodal para el tinnitus”. Los investigadores han comenzado otro gran estudio con el fin de ajustar la técnica.

El descubrimiento accidental

El desarrollo del dispositivo surgió de un descubrimiento accidental. El Dr. Lim de Minnesota estaba realizando una estimulación cerebral profunda en un paciente con tinnitus. El electrodo se salió de su curso, tocando otras áreas del cerebro, y el paciente estaba emocionado de decir que ya no podía escuchar su tinnitus.

Fuente: Infoacufenos.com

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